The PYRIN connection: novel players in innate immunity and inflammation.
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ABSTRACT:
SUBMITTER: Stehlik C
PROVIDER: S-EPMC2212741 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Publications
The PYRIN connection: novel players in innate immunity and inflammation.
Stehlik Christian C Reed John C JC
The Journal of experimental medicine 20040901 5
Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs. ...[more]
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