Ontology highlight
ABSTRACT:
SUBMITTER: Miyaji M
PROVIDER: S-EPMC2213006 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Miyaji Michihiko M Jin Zhe-Xiong ZX Yamaoka Shohei S Amakawa Ryuichi R Fukuhara Shirou S Sato Satoshi B SB Kobayashi Toshihide T Domae Naochika N Mimori Tsuneyo T Bloom Eda T ET Okazaki Toshiro T Umehara Hisanori H
The Journal of experimental medicine 20050711 2
Engagement of the Fas receptor (CD95) initiates multiple signaling pathways that lead to apoptosis, such as the formation of death-inducing signaling complex (DISC), activation of caspase cascades, and the generation of the lipid messenger, ceramide. Sphingomyelin (SM) is a major component of lipid rafts, which are specialized structures that enhance the efficiency of membrane receptor signaling and are a main source of ceramide. However, the functions of SM in Fas-mediated apoptosis have yet to ...[more]