Ontology highlight
ABSTRACT:
SUBMITTER: Pascual V
PROVIDER: S-EPMC2213182 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Pascual Virginia V Allantaz Florence F Arce Edsel E Punaro Marilynn M Banchereau Jacques J
The Journal of experimental medicine 20050425 9
Systemic onset juvenile idiopathic arthritis (SoJIA) encompasses approximately 10% of cases of arthritis that begin in childhood. The disease is unique in terms of clinical manifestations, severity of joint involvement, and lack of response to tumor necrosis factor blockade. Here, we show that serum from SoJIA patients induces the transcription of innate immunity genes, including interleukin (IL)-1 in healthy peripheral blood mononuclear cells (PBMCs). Upon activation, SoJIA PBMCs release large ...[more]