Ontology highlight
ABSTRACT:
SUBMITTER: Ray SC
PROVIDER: S-EPMC2213258 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Ray Stuart C SC Fanning Liam L Wang Xiao-Hong XH Netski Dale M DM Kenny-Walsh Elizabeth E Thomas David L DL
The Journal of experimental medicine 20050601 11
The genomic sequences of viruses that are highly mutable and cause chronic infection tend to diverge over time. We report that these changes represent both immune-driven selection and, in the absence of immune pressure, reversion toward an ancestral consensus. Sequence changes in hepatitis C virus (HCV) structural and nonstructural genes were studied in a cohort of women accidentally infected with HCV in a rare common-source outbreak. We compared sequences present in serum obtained 18-22 yr afte ...[more]