Ontology highlight
ABSTRACT:
SUBMITTER: Schroder GF
PROVIDER: S-EPMC2213367 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Schröder Gunnar F GF Brunger Axel T AT Levitt Michael M
Structure (London, England : 1993) 20071201 12
Structural studies of large proteins and protein assemblies are a difficult and pressing challenge in molecular biology. Experiments often yield only low-resolution or sparse data that are not sufficient to fully determine atomistic structures. We have developed a general geometry-based algorithm that efficiently samples conformational space under constraints imposed by low-resolution density maps obtained from electron microscopy or X-ray crystallography experiments. A deformable elastic networ ...[more]