Eya4-deficient mice are a model for heritable otitis media.
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ABSTRACT:
SUBMITTER: Depreux FF
PROVIDER: S-EPMC2213371 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Publications
Eya4-deficient mice are a model for heritable otitis media.
Depreux Frederic F S FF Darrow Keith K Conner David A DA Eavey Roland D RD Liberman M Charles MC Seidman Christine E CE Seidman J G JG
The Journal of clinical investigation 20080201 2
Otitis media is an extremely common pediatric inflammation of the middle ear that often causes pain and diminishes hearing. Vulnerability to otitis media is due to eustachian tube dysfunction as well as other poorly understood factors, including genetic susceptibility. As EYA4 mutations cause sensorineural hearing loss in humans, we produced and characterized Eya4-deficient (Eya4(-/-)) mice, which had severe hearing deficits. In addition, all Eya4(-/-) mice developed otitis media with effusion. ...[more]
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