Ontology highlight
ABSTRACT:
SUBMITTER: Moreau-Aubry A
PROVIDER: S-EPMC2213434 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
Moreau-Aubry A A Le Guiner S S Labarrière N N Gesnel M C MC Jotereau F F Breathnach R R
The Journal of experimental medicine 20000501 9
The M88.7 T cell clone recognizes an antigen presented by HLA B*1302 on the melanoma cell line M88. A cDNA encoding this antigen (NA88-A) was isolated using a library transfection approach. Analysis of the genomic gene's sequence identified it is a processed pseudogene, derived from a retrotranscript of mRNA coding for homeoprotein HPX42B. The NA88-A gene exhibits several premature stop codons, deletions, and insertions relative to the HPX42B gene. In NA88-A RNA, a short open reading frame codes ...[more]