Ontology highlight
ABSTRACT:
SUBMITTER: Millon-Fremillon A
PROVIDER: S-EPMC2213582 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Millon-Frémillon Angélique A Bouvard Daniel D Grichine Alexei A Manet-Dupé Sandra S Block Marc R MR Albiges-Rizo Corinne C
The Journal of cell biology 20080101 2
Cell migration is an integrated process requiring the continuous coordinated assembly and disassembly of adhesion structures. How cells orchestrate adhesion turnover is only partially understood. We provide evidence for a novel mechanistic insight into focal adhesion (FA) dynamics by demonstrating that integrin cytoplasmic domain-associated protein 1 (ICAP-1) slows down FA assembly. Live cell imaging, which was performed in both Icap-1-deficient mouse embryonic fibroblasts and cells expressing a ...[more]