Ontology highlight
ABSTRACT:
SUBMITTER: Lowe JS
PROVIDER: S-EPMC2213608 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Lowe John S JS Palygin Oleg O Bhasin Naina N Hund Thomas J TJ Boyden Penelope A PA Shibata Erwin E Anderson Mark E ME Mohler Peter J PJ
The Journal of cell biology 20080107 1
Voltage-gated Na(v) channels are required for normal electrical activity in neurons, skeletal muscle, and cardiomyocytes. In the heart, Na(v)1.5 is the predominant Na(v) channel, and Na(v)1.5-dependent activity regulates rapid upstroke of the cardiac action potential. Na(v)1.5 activity requires precise localization at specialized cardiomyocyte membrane domains. However, the molecular mechanisms underlying Na(v) channel trafficking in the heart are unknown. In this paper, we demonstrate that anky ...[more]