Molecular pathogenesis of emphysema.
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ABSTRACT:
SUBMITTER: Taraseviciene-Stewart L
PROVIDER: S-EPMC2214683 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Publications
Molecular pathogenesis of emphysema.
Taraseviciene-Stewart Laimute L Voelkel Norbert F NF
The Journal of clinical investigation 20080201 2
Emphysema is one manifestation of a group of chronic, obstructive, and frequently progressive destructive lung diseases. Cigarette smoking and air pollution are the main causes of emphysema in humans, and cigarette smoking causes emphysema in rodents. This review examines the concept of a homeostatically active lung structure maintenance program that, when attacked by proteases and oxidants, leads to the loss of alveolar septal cells and airspace enlargement. Inflammatory and noninflammatory mec ...[more]
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