Ontology highlight
ABSTRACT:
SUBMITTER: Labro AJ
PROVIDER: S-EPMC2217479 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Labro Alain J AJ Raes Adam L AL Snyders Dirk J DJ
The Journal of general physiology 20050101 1
Voltage-gated K(+) channels play a central role in the modulation of excitability. In these channels, the voltage-dependent movement of the voltage sensor (primarily S4) is coupled to the (S6) gate that opens the permeation pathway. Because of the tetrameric structure, such coupling could occur within each subunit or between adjacent subunits. To discriminate between these possibilities, we analyzed various combinations of a S4 mutation (R401N) and a S6 mutation (P511G) in hKv1.5, incorporated i ...[more]