Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC2217590 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Yu Xinhua X Koczan Dirk D Sulonen Anna-Maija AM Akkad Denis A DA Kroner Antje A Comabella Manuel M Costa Gianna G Corongiu Daniela D Goertsches Robert R Camina-Tato Montserrat M Thiesen Hans-Juergen HJ Nyland Harald I HI Mørk Sverre J SJ Montalban Xavier X Rieckmann Peter P Marrosu Maria G MG Myhr Kjell-Morten KM Epplen Joerg T JT Saarela Janna J Ibrahim Saleh M SM
PloS one 20080213 2
<h4>Background</h4>Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility.<h4>Methods and findings</h4>In order to investigate the role of mtDNA variations in MS, we investigated six European MS case-control cohorts comprising >5,000 individuals. Three well matched cohorts were genotyped with seven common, potentially functional mtDNA single nucleotide polymorphisms (SNPs). A SNP, nt13708 G/A, was ...[more]