Ontology highlight
ABSTRACT:
SUBMITTER: Carlson CB
PROVIDER: S-EPMC2219892 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Carlson C Britt CB Bernstein Douglas A DA Annis Douglas S DS Misenheimer Tina M TM Hannah Blue-leaf A BL Mosher Deane F DF Keck James L JL
Nature structural & molecular biology 20050925 10
Thrombospondins (THBSs) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix. Here, we describe the 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2, which includes three epidermal growth factor-like modules, 13 aspartate-rich repeats and a lectin-like module. These elements interact extensively to form three structural regions termed the stalk, wire and globe. The THBS2 signature domain is stabilized by t ...[more]