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ABSTRACT:
SUBMITTER: Safo MK
PROVIDER: S-EPMC2222568 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Safo Martin K MK Ko Tzu Ping TP Musayev Faik N FN Zhao Qixun Q Wang Andrew H J AH Archer Gordon L GL
Acta crystallographica. Section F, Structural biology and crystallization communications 20060325 Pt 4
The dimeric repressor MecI regulates the mecA gene that encodes the penicillin-binding protein PBP-2a in methicillin-resistant Staphylococcus aureus (MRSA). MecI is similar to BlaI, the repressor for the blaZ gene of beta-lactamase. MecI and BlaI can bind to both operator DNA sequences. The crystal structure of MecI in complex with the 32 base-pair cognate DNA of mec was determined to 3.8 A resolution. MecI is a homodimer and each monomer consists of a compact N-terminal winged-helix domain, whi ...[more]