Ontology highlight
ABSTRACT:
SUBMITTER: Zhang R
PROVIDER: S-EPMC2222583 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Zhang Rongguang R Skarina Tatiana T Evdokimova Elena E Edwards Aled A Savchenko Alexei A Laskowski Roman R Cuff Marianne E ME Joachimiak Andrzej A
Acta crystallographica. Section F, Structural biology and crystallization communications 20060325 Pt 4
As a part of a structural genomics program, the 2.2 angstroms resolution crystal structure of the PurC gene product from Thermotoga maritima has been solved. This 26.2 kDa protein belongs to the phophoribosylaminoimidazole-succinocarboxamide or SAICAR synthase family of enzymes, the members of which are involved in de novo purine biosynthesis. SAICAR synthase can be divided into three subdomains: two alpha+beta regions exhibiting structural homology with ATP-binding proteins and a carboxy-termin ...[more]