Ontology highlight
ABSTRACT:
SUBMITTER: Johnstone CN
PROVIDER: S-EPMC2223422 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Johnstone Cameron N CN Mongroo Perry S PS Rich A Sophie AS Schupp Michael M Bowser Mark J MJ Delemos Andrew S AS Tobias John W JW Liu Yingqiu Y Hannigan Gregory E GE Rustgi Anil K AK
Molecular and cellular biology 20071112 2
Parvin-beta is a focal adhesion protein downregulated in human breast cancer cells. Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracellular matrix in vitro. The effect of ectopic Parvin-beta expression on the transcriptional profile of MDA-MB-231 breast cancer cells, which normally do not express Parvin-beta, was evaluated. Particular emphasis was placed upon propagating MDA-MB-231 breast cancer cells in three-dim ...[more]