Modulation of horizontally acquired genes by the Hha-YdgT proteins in Salmonella enterica serovar Typhimurium.
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ABSTRACT:
SUBMITTER: Vivero A
PROVIDER: S-EPMC2223552 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Publications
Modulation of horizontally acquired genes by the Hha-YdgT proteins in Salmonella enterica serovar Typhimurium.
Vivero Aitziber A Baños Rosa C RC Mariscotti Javier F JF Oliveros Juan Carlos JC García-del Portillo Francisco F Juárez Antonio A Madrid Cristina C
Journal of bacteriology 20071126 3
We describe a transcriptomic study of the effect of hha and ydgT mutations in Salmonella enterica serovar Typhimurium. A large number of genes showing altered expression are located in AT-rich horizontally acquired DNA sequences. Many of these genes have also been reported to be targets for H-NS. As Hha and YdgT interact with H-NS, our findings strongly suggest that Hha and/or YdgT must form complexes with H-NS when they silence these DNA regions. ...[more]
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