Ontology highlight
ABSTRACT:
SUBMITTER: Collins MD
PROVIDER: S-EPMC2224171 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Collins Marcus D MD Keller Sarah L SL
Proceedings of the National Academy of Sciences of the United States of America 20080102 1
Plasma membranes of cells are asymmetric in both lipid and protein composition. The mechanism by which proteins on both sides of the membrane colocalize during signaling events is unknown but may be due to the induction of inner leaflet domains by the outer leaflet. Here we show that liquid domains form in asymmetric Montal-Mueller planar bilayers in which one leaflet's composition would phase-separate in a symmetric bilayer and the other's would not. Equally important, by tuning the lipid compo ...[more]