Ontology highlight
ABSTRACT:
SUBMITTER: Soupene E
PROVIDER: S-EPMC2224237 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Soupene Eric E Fyrst Henrik H Kuypers Frans A FA
Proceedings of the National Academy of Sciences of the United States of America 20071221 1
The mammalian RBC lacks de novo lipid synthesis but maintains its membrane composition by rapid turnover of acyl moieties at the sn-2 position of phospholipids. Plasma-derived fatty acids are esterified to acyl-CoA by acyl-CoA synthetases and transferred to lysophospholipids by acyl-CoA:lysophospholipid acyltransferases. We report the characterization of three lysophosphatidylcholine (lysoPC) acyltransferases (LPCATs), products of the AYTL1, -2, and -3 genes. These proteins are three members of ...[more]