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Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru.


ABSTRACT: The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC2224716 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature

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Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru.

Zhou Zhiyong Z   Griffing Sean M SM   de Oliveira Alexandre Macedo AM   McCollum Andrea M AM   Quezada Wilmer Marquino WM   Arrospide Nancy N   Escalante Ananias A AA   Udhayakumar Venkatachalam V  

Antimicrobial agents and chemotherapy 20071119 2


The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin. ...[more]

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