Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC2224716 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Zhou Zhiyong Z Griffing Sean M SM de Oliveira Alexandre Macedo AM McCollum Andrea M AM Quezada Wilmer Marquino WM Arrospide Nancy N Escalante Ananias A AA Udhayakumar Venkatachalam V
Antimicrobial agents and chemotherapy 20071119 2
The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin. ...[more]