Analysis of the beta-tubulin gene from Vittaforma corneae suggests benzimidazole resistance.
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ABSTRACT:
SUBMITTER: Franzen C
PROVIDER: S-EPMC2224753 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
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Analysis of the beta-tubulin gene from Vittaforma corneae suggests benzimidazole resistance.
Franzen Caspar C Salzberger Bernd B
Antimicrobial agents and chemotherapy 20071203 2
We amplified, cloned, and sequenced the beta-tubulin gene of Vittaforma corneae, a microsporidium causing human infections. The beta-tubulin gene sequence has a substitution at Glu(198) (with glutamine), which is one of six amino acids reported to be associated with benzimidazole sensitivity. Benzimidazoles were assayed for antimicrosporidial activity and showed poor parasite inhibition. ...[more]
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