Unknown

Dataset Information

0

A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland.


ABSTRACT: BACKGROUND: A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families with affected siblings from Finland, a population expected to be more genetically homogeneous than others, and having the highest incidence of type 1 diabetes in the world and, yet, the highest proportion in Europe of cases (10%) carrying neither of the highest risk HLA haplotypes that include DR3 or DR4 alleles. RESULTS: In addition to the evidence of linkage to the HLA region on 6p21 (nominal p = 4.0 x 10-6), significant evidence of linkage in other chromosome regions was not detected with a single-locus analysis. The two-locus analysis conditional on the HLA gave a maximum lod score (MLS) of 3.1 (nominal p = 2 x 10-4) on chromosome 9p13 under an additive model; MLS of 2.1 (nominal p = 6.1 x 10-3) on chromosome 17p12 and MLS of 2.5 (nominal p = 2.9 x 10-3) on chromosome 18p11 under a general model. CONCLUSION: Our genome scan data confirmed the primary contribution of the HLA genes also in the high-risk Finnish population, and suggest that non-HLA genes also contribute to the familial clustering of type 1 diabetes in Finland.

SUBMITTER: Qiao Q 

PROVIDER: S-EPMC2225422 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature

altmetric image

Publications

A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland.

Qiao Qing Q   Osterholm Anne-May AM   He Bing B   Pitkäniemi Janne J   Cordell Heather J HJ   Sarti Cinzia C   Kinnunen Leena L   Tuomilehto-Wolf Eva E   Tryggvason Karl K   Tuomilehto Jaakko J  

BMC genetics 20071219


<h4>Background</h4>A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families with affected siblings from Finland, a population expected to be more genetically homogeneous than others, and having the highest incidence of type 1 diabetes in the world and, yet, the highest proportion in Europe of cases (10%) carrying neither of the highest risk HLA haplotypes that include DR3 or DR4 alleles.<h4>Resu  ...[more]

Similar Datasets

| S-EPMC2956012 | biostudies-literature
| S-EPMC2682673 | biostudies-literature
| S-EPMC1785345 | biostudies-literature
| S-EPMC2661598 | biostudies-literature
| S-EPMC16660 | biostudies-other
| S-EPMC1235542 | biostudies-literature
| S-EPMC3251509 | biostudies-literature
| S-EPMC1216055 | biostudies-literature
| S-EPMC3137914 | biostudies-literature