Ontology highlight
ABSTRACT:
SUBMITTER: Qiao Q
PROVIDER: S-EPMC2225422 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Qiao Qing Q Osterholm Anne-May AM He Bing B Pitkäniemi Janne J Cordell Heather J HJ Sarti Cinzia C Kinnunen Leena L Tuomilehto-Wolf Eva E Tryggvason Karl K Tuomilehto Jaakko J
BMC genetics 20071219
<h4>Background</h4>A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families with affected siblings from Finland, a population expected to be more genetically homogeneous than others, and having the highest incidence of type 1 diabetes in the world and, yet, the highest proportion in Europe of cases (10%) carrying neither of the highest risk HLA haplotypes that include DR3 or DR4 alleles.<h4>Resu ...[more]