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ABSTRACT: Aims
Overactive bladder (OAB) is common in men and may exist concomitantly with benign prostatic hyperplasia (BPH) and obstruction. We present a subanalysis of results from men with OAB in a 6-month, open-label study of treatment with the oxybutynin transdermal system (OXY-TDS). Broad entry criteria were incorporated to yield a clinically representative population.Methods
All participants received OXY-TDS 3.9 mg/day. Effectiveness was assessed by changes in scores on validated questionnaires, which included the single-item Patient Perception of Bladder Condition (PPBC), the King's Health Questionnaire (KHQ) and the Beck Depression Inventory-II (BDI-II).Results
The proportion of men (n=369; mean age=69.6 years) who reported that their bladder condition caused moderate, severe or many severe problems (PPBC>or=4) improved from 77.3% at baseline to 38.1-53.6% in subsequent months. Mean KHQ scores decreased significantly (pConclusions
Oxybutynin transdermal system treatment of men with OAB was effective and well tolerated, regardless of history of prostate condition.
SUBMITTER: Staskin DR
PROVIDER: S-EPMC2228367 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Staskin D R DR Rosenberg M T MT Dahl N V NV Polishuk P V PV Zinner N R NR
International journal of clinical practice 20071115 1
<h4>Aims</h4>Overactive bladder (OAB) is common in men and may exist concomitantly with benign prostatic hyperplasia (BPH) and obstruction. We present a subanalysis of results from men with OAB in a 6-month, open-label study of treatment with the oxybutynin transdermal system (OXY-TDS). Broad entry criteria were incorporated to yield a clinically representative population.<h4>Methods</h4>All participants received OXY-TDS 3.9 mg/day. Effectiveness was assessed by changes in scores on validated qu ...[more]