Ontology highlight
ABSTRACT:
SUBMITTER: Kienker PK
PROVIDER: S-EPMC2229546 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Kienker Paul K PK Jakes Karen S KS Blaustein Robert O RO Miller Christopher C Finkelstein Alan A
The Journal of general physiology 20030714 2
The bacterial toxin colicin Ia forms voltage-gated channels in planar lipid bilayers. The toxin consists of three domains, with the carboxy-terminal domain (C-domain) responsible for channel formation. The C-domain contributes four membrane-spanning segments and a 68-residue translocated segment to the open channel, whereas the upstream domains and the amino-terminal end of the C-domain stay on the cis side of the membrane. The isolated C-domain, lacking the two upstream domains, also forms chan ...[more]