Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC2230593 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Kim Jeongki J Shao Yan Y Kim Sang Yong SY Kim Seyl S Song Hyun Keun HK Jeon Jun Ho JH Suh Hyun Woo HW Chung Jin Woong JW Yoon Suk Ran SR Kim Young Sang YS Choi Inpyo I
Molecular biology of the cell 20071114 2
Interleukin-18 (IL-18) plays pivotal roles in linking inflammatory immune responses and tumor progression and metastasis, yet the manner in which this occurs remains to be sufficiently clarified. Here we report that hypoxia induces the transcription and secretion of IL-18, which subsequently induces the expression of hypoxia-inducible factor-1alpha (HIF-1alpha). Mechanistically, IL-18 induces HIF-1alpha through the activity of the GTPase Rac1, which inducibly associates with the IL-18 receptor b ...[more]