Ontology highlight
ABSTRACT:
SUBMITTER: Bonnert TP
PROVIDER: S-EPMC22306 | biostudies-literature | 1999 Aug
REPOSITORIES: biostudies-literature
Bonnert T P TP McKernan R M RM Farrar S S le Bourdellès B B Heavens R P RP Smith D W DW Hewson L L Rigby M R MR Sirinathsinghji D J DJ Brown N N Wafford K A KA Whiting P J PJ
Proceedings of the National Academy of Sciences of the United States of America 19990801 17
gamma-Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory neurotransmission in the mammalian central nervous system, and the site of action of a number of clinically important drugs. These receptors exist as a family of subtypes with distinct temporal and spatial patterns of expression and distinct properties that presumably underlie a precise role for each subtype. The newest member of this gene family is the theta subunit. The deduced polypeptide sequence is 627 amin ...[more]