Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell JM
PROVIDER: S-EPMC2231809 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Mitchell J M JM Hicklin D M DM Doughty P M PM Hicklin J H JH Dickert J W JW Tolbert S M SM Peterkova R R Kern M J MJ
Journal of dental research 20061001 10
The paired-related homeobox genes, Prx1 and Prx2, encode transcription factors critical for orofacial development. Prx1(-/-)/Prx2(-/-) neonates have mandibular hypoplasia and malformed mandibular incisors. Although the mandibular incisor phenotype has been briefly described (ten Berge et al., 1998, 2001; Lu et al., 1999), very little is known about the role of Prx proteins during tooth morphogenesis. Since the posterior mandibular region was relatively normal, we examined molar tooth development ...[more]