Gating kinetics of the alpha1I T-type calcium channel.
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ABSTRACT:
SUBMITTER: Frazier CJ
PROVIDER: S-EPMC2233834 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Publications
Gating kinetics of the alpha1I T-type calcium channel.
Frazier C J CJ Serrano J R JR George E G EG Yu X X Viswanathan A A Perez-Reyes E E Jones S W SW
The Journal of general physiology 20011101 5
The alpha1I T-type calcium channel inactivates almost 10-fold more slowly than the other family members (alpha1G and alpha1H) or most native T-channels. We have examined the underlying mechanisms using whole-cell recordings from rat alpha1I stably expressed in HEK293 cells. We found several kinetic differences between alpha1G and alpha1I, including some properties that at first appear qualitatively different. Notably, alpha1I tail currents require two or even three exponentials, whereas alpha1G ...[more]
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