Ontology highlight
ABSTRACT:
SUBMITTER: Lim ST
PROVIDER: S-EPMC2234035 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Lim Ssang-Taek ST Chen Xiao Lei XL Lim Yangmi Y Hanson Dan A DA Vo Thanh-Trang TT Howerton Kyle K Larocque Nicholas N Fisher Susan J SJ Schlaepfer David D DD Ilic Dusko D
Molecular cell 20080101 1
FAK is known as an integrin- and growth factor-associated tyrosine kinase promoting cell motility. Here we show that, during mouse development, FAK inactivation results in p53- and p21-dependent mesodermal cell growth arrest. Reconstitution of primary FAK-/-p21-/- fibroblasts revealed that FAK, in a kinase-independent manner, facilitates p53 turnover via enhanced Mdm2-dependent p53 ubiquitination. p53 inactivation by FAK required FAK FERM F1 lobe binding to p53, FERM F2 lobe-mediated nuclear loc ...[more]