Ontology highlight
ABSTRACT:
SUBMITTER: Clayton GM
PROVIDER: S-EPMC2234175 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Clayton Gina M GM Altieri Steve S Heginbotham Lise L Unger Vinzenz M VM Morais-Cabral João H JH
Proceedings of the National Academy of Sciences of the United States of America 20080123 5
The six-transmembrane helix (6 TM) tetrameric cation channels form the largest ion channel family, some members of which are voltage-gated and others are not. There are no reported channel structures to match the wealth of functional data on the non-voltage-gated members. We determined the structure of the transmembrane regions of the bacterial cyclic nucleotide-regulated channel MlotiK1, a non-voltage-gated 6 TM channel. The structure showed how the S1-S4 domain and its associated linker can se ...[more]