Ontology highlight
ABSTRACT:
SUBMITTER: Haque ME
PROVIDER: S-EPMC2234210 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Haque M Emdadul ME Thomas Kelly J KJ D'Souza Cheryl C Callaghan Steve S Kitada Tohru T Slack Ruth S RS Fraser Paul P Cookson Mark R MR Tandon Anurag A Park David S DS
Proceedings of the National Academy of Sciences of the United States of America 20080124 5
PTEN-induced putative kinase 1 (Pink1) is a recently identified gene linked to a recessive form of familial Parkinson's disease (PD). The kinase contains a mitochondrial localization sequence and is reported to reside, at least in part, in mitochondria. However, neither the manner by which the loss of Pink1 contributes to dopamine neuron loss nor its impact on mitochondrial function and relevance to death is clear. Here, we report that depletion of Pink1 by RNAi increased neuronal toxicity induc ...[more]