Ontology highlight
ABSTRACT:
SUBMITTER: Twig G
PROVIDER: S-EPMC2234339 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Twig Gilad G Elorza Alvaro A Molina Anthony J A AJ Mohamed Hibo H Wikstrom Jakob D JD Walzer Gil G Stiles Linsey L Haigh Sarah E SE Katz Steve S Las Guy G Alroy Joseph J Wu Min M Py Bénédicte F BF Yuan Junying J Deeney Jude T JT Corkey Barbara E BE Shirihai Orian S OS
The EMBO journal 20080117 2
Accumulation of depolarized mitochondria within beta-cells has been associated with oxidative damage and development of diabetes. To determine the source and fate of depolarized mitochondria, individual mitochondria were photolabeled and tracked through fusion and fission. Mitochondria were found to go through frequent cycles of fusion and fission in a 'kiss and run' pattern. Fission events often generated uneven daughter units: one daughter exhibited increased membrane potential (delta psi(m)) ...[more]