Ontology highlight
ABSTRACT:
SUBMITTER: Pal U
PROVIDER: S-EPMC2234379 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Pal Utpal U Wang Penghua P Bao Fukai F Yang Xiuli X Samanta Swapna S Schoen Robert R Wormser Gary P GP Schwartz Ira I Fikrig Erol E
The Journal of experimental medicine 20071231 1
Lyme arthritis results from colonization of joints by Borrelia burgdorferi and the ensuing host response. Using gene array-based differential analysis of B. burgdorferi gene expression and quantitative reverse trancription-polymerase chain reaction, we identified two paralogous spirochete genes, bmpA and bmpB, that are preferentially up-regulated in mouse joints compared with other organs. Transfer of affinity-purified antibodies against either BmpA or BmpB into B. burgdorferi-infected mice sele ...[more]