Ontology highlight
ABSTRACT:
SUBMITTER: Agarwal N
PROVIDER: S-EPMC2234438 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Nature neuroscience 20070610 7
Although endocannabinoids constitute one of the first lines of defense against pain, the anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of pain are uncertain. Clinical exploitation of the system is severely hindered by the cognitive deficits, memory impairment, motor disturbances and psychotropic effects resulting from the central actions of cannabinoids. We deleted the type 1 cannabinoid receptor (CB1) specifically in nociceptive neurons localized in th ...[more]