Ontology highlight
ABSTRACT:
SUBMITTER: Sankaran VG
PROVIDER: S-EPMC2238668 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Genes & development 20080207 4
Regulation of the cell cycle is intimately linked to erythroid differentiation, yet how these processes are coupled is not well understood. To gain insight into this coordinate regulation, we examined the role that the retinoblastoma protein (Rb), a central regulator of the cell cycle, plays in erythropoiesis. We found that Rb serves a cell-intrinsic role and its absence causes ineffective erythropoiesis, with a differentiation block at the transition from early to late erythroblasts. Unexpected ...[more]