Ontology highlight
ABSTRACT:
SUBMITTER: Zhang JY
PROVIDER: S-EPMC2239246 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Zhang Jennifer Y JY Adams Amy E AE Ridky Todd W TW Tao Shiying S Khavari Paul A PA
Cancer research 20070401 8
The tumor necrosis factor alpha receptor (TNFR1) activates downstream effectors that include the mitogen-activated protein kinase kinase 7 (MKK7)/c-Jun-NH(2)-kinase (JNK)/activator protein 1 (AP1) cascade. Here, we report that JNK is activated in a majority of spontaneous human squamous cell carcinomas (SCC). JNK pathway induction bypassed cell cycle restraints induced by oncogenic Ras and cooperated with Ras to convert normal human epidermis into tumors indistinguishable from SCC, confirming it ...[more]