Structural interpretation of mutations and SNPs using STRAP-NT.

ABSTRACT: Visualization of residue positions in protein alignments and mapping onto suitable structural models is an important first step in the interpretation of mutations or polymorphisms in terms of protein function, interaction, and thermodynamic stability. Selecting and highlighting large numbers of residue positions in a protein structure can be time-consuming and tedious with currently available software. Previously, a series of tasks and analyses had to be performed one-by-one to map mutations onto 3D protein structures; STRAP-NT is an extension of STRAP that automates these tasks so that users can quickly and conveniently map mutations onto 3D protein structures. When the structure of the protein of interest is not yet available, a related protein can frequently be found in the structure da

SUBMITTER: Gille C 

PROVIDER: S-EPMC2242373 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature