Ontology highlight
ABSTRACT:
SUBMITTER: Tochio N
PROVIDER: S-EPMC2242405 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20061101 11
Microtubule-associated protein/microtubule affinity-regulating kinases (MARKs)/PAR-1 are common regulators of cell polarity that are conserved from nematode to human. All of these kinases have a highly conserved C-terminal domain, which is termed the kinase-associated domain 1 (KA1), although its function is unknown. In this study, we determined the solution structure of the KA1 domain of mouse MARK3 by NMR spectroscopy. We found that approximately 50 additional residues preceding the previously ...[more]