Ligand binding by TPR domains.
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ABSTRACT:
SUBMITTER: Cortajarena AL
PROVIDER: S-EPMC2242500 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Publications
Ligand binding by TPR domains.
Cortajarena Aitziber L AL Regan Lynne L
Protein science : a publication of the Protein Society 20060501 5
Tetratricopeptide repeat (TPR) domains bind specific peptide ligands and are thought to mediate protein-protein interactions in a variety of biological systems. Here we compare peptide ligand-binding by several different TPR domains. We present specific examples that demonstrate that TPR domains typically undergo little or no structural rearrangement upon ligand binding. Our data suggest that, contrary to a recent proposal, coupled folding and binding is not the common mechanism of ligand recogn ...[more]
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