Ontology highlight
ABSTRACT:
SUBMITTER: Sevostyanova A
PROVIDER: S-EPMC2242686 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Sevostyanova Anastasiya A Svetlov Vladimir V Vassylyev Dmitry G DG Artsimovitch Irina I
Proceedings of the National Academy of Sciences of the United States of America 20080114 3
RNA polymerase is a target for numerous regulatory events in all living cells. Recent studies identified a few "hot spots" on the surface of bacterial RNA polymerase that mediate its interactions with diverse accessory proteins. Prominent among these hot spots, the beta' subunit clamp helices serve as a major binding site for the initiation factor sigma and for the elongation factor RfaH. Furthermore, the two proteins interact with the nontemplate DNA strand in transcription complexes and thus m ...[more]