Ontology highlight
ABSTRACT:
SUBMITTER: Gold MC
PROVIDER: S-EPMC2242840 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Gold Marielle C MC Ehlinger Heather D HD Cook Matthew S MS Smyk-Pearson Susan K SK Wille Paul T PT Ungerleider Ross M RM Lewinsohn Deborah A DA Lewinsohn David M DM
PLoS pathogens 20080201 2
The control of Mycobacterium tuberculosis (Mtb) infection is heavily dependent on the adaptive Th1 cellular immune response. Paradoxically, optimal priming of the Th1 response requires activation of priming dendritic cells with Th1 cytokine IFN-gamma. At present, the innate cellular mechanisms required for the generation of an optimal Th1 T cell response remain poorly characterized. We hypothesized that innate Mtb-reactive T cells provide an early source of IFN-gamma to fully activate Mtb-expose ...[more]