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ABSTRACT:
SUBMITTER: Kitatani T
PROVIDER: S-EPMC2242934 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Kitatani Tomoya T Nakamura Yoshihiro Y Wada Kei K Kinoshita Takayoshi T Tamoi Masahiro M Shigeoka Shigeru S Tada Toshiji T
Acta crystallographica. Section F, Structural biology and crystallization communications 20060729 Pt 8
The crystal structure of NADP-dependent apo-glyceraldehyde-3-phosphate dehydrogenase (apo-GAPDH) from Synechococcus PCC 7942 is reported. The crystal structure was solved by molecular replacement and refined to an R of 21.7% and R(free) of 27.5% at 2.9 angstroms resolution. The structural features of apo-GAPDH are as follows. The S-loop has an extremely flexible conformation and the sulfate ion is only taken into the classical P(i) site. A structural comparison with holo-GAPDHs indicated that th ...[more]