Ontology highlight
ABSTRACT:
SUBMITTER: Palstra RJ
PROVIDER: S-EPMC2243019 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Palstra Robert-Jan RJ Simonis Marieke M Klous Petra P Brasset Emilie E Eijkelkamp Bart B de Laat Wouter W
PloS one 20080220 2
A relationship exists between nuclear architecture and gene activity and it has been proposed that the activity of ongoing RNA polymerase II transcription determines genome organization in the mammalian cell nucleus. Recently developed 3C and 4C technology allowed us to test the importance of transcription for nuclear architecture. We demonstrate that upon transcription inhibition binding of RNA polymerase II to gene regulatory elements is severely reduced. However, contacts between regulatory D ...[more]