Understanding protein folding: small proteins in silico.
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ABSTRACT:
SUBMITTER: Zimmermann O
PROVIDER: S-EPMC2244683 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Publications
Understanding protein folding: small proteins in silico.
Zimmermann Olav O Hansmann Ulrich H E UH
Biochimica et biophysica acta 20071106 1
Recent improvements in methodology and increased computer power now allow atomistic computer simulations of protein folding. We briefly review several advanced Monte Carlo algorithms that have contributed to this development. Details of folding simulations of three designed mini proteins are shown. Adding global translations and rotations has allowed us to handle multiple chains and to simulate the aggregation of six beta-amyloid fragments. In a different line of research we have developed sever ...[more]
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