Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC2245859 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Yang Li L Huang Jianhua J Ren Xiubao X Gorska Agnieszka E AE Chytil Anna A Aakre Mary M Carbone David P DP Matrisian Lynn M LM Richmond Ann A Lin P Charles PC Moses Harold L HL
Cancer cell 20080101 1
Aberrant TGFbeta signaling is common in human cancers and contributes to tumor metastasis. Here, we demonstrate that Gr-1+CD11b+ myeloid cells are recruited into mammary carcinomas with type II TGF beta receptor gene (Tgfbr2) deletion and directly promote tumor metastasis. Gr-1+CD11b+ cells infiltrate into the invasive front of tumor tissues and facilitate tumor cell invasion and metastasis through a process involving metalloproteinase activity. This infiltration of Gr-1+CD11b+ cells also result ...[more]