The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors.

ABSTRACT:

Background

G protein-coupled receptors (GPCRs) are one of the largest families of genes in mammals. Branchiostoma floridae (amphioxus) is one of the species most closely related species to vertebrates.

Results

Mining and phylogenetic analysis of the amphioxus genome showed the presence of at least 664 distinct GPCRs distributed among all the main families of GPCRs; Glutamate (18), Rhodopsin (570), Adhesion (37), Frizzled (6) and Secretin (16). Surprisingly, the Adhesion GPCR repertoire in amphioxus includes receptors with many new domains not previously observed in this family. We found many Rhodopsin GPCRs from all main groups including many amine and peptide binding receptors and several previously uncharacterized expansions were also identified. This genome has however no

SUBMITTER: Nordstrom KJ 

PROVIDER: S-EPMC2246102 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature