Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes.
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ABSTRACT:
SUBMITTER: Nordgard SH
PROVIDER: S-EPMC2246167 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes.
Nordgard Silje H SH Johansen Fredrik E FE Alnaes Grethe I G GI Naume Bjørn B Børresen-Dale Anne-Lise AL Kristensen Vessela N VN
Breast cancer research : BCR 20070101 6
Recently, genome-wide association studies of breast cancer revealed single nucleotide polymorphisms (SNPs) in five genes with novel association to susceptibility. While there is little doubt that the novel susceptibility markers produced from such highly powered studies are true, the mechanisms by which they cause the susceptibility remain undetermined. We have looked at the expression levels of the identified genes in tumours and found that they are highly significantly differentially expressed ...[more]
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