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Determining promoter location based on DNA structure first-principles calculations.

ABSTRACT: A new method for the prediction of promoter regions based on atomic molecular dynamics simulations of small oligonucleotides has been developed. The method works independently of gene structure conservation and orthology and of the presence of detectable sequence features. Results obtained with our method confirm the existence of a hidden physical code that modulates genome expression.

SUBMITTER: Goni JR

PROVIDER: S-EPMC2246265 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature

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Determining promoter location based on DNA structure first-principles calculations.

Goñi J Ramon JR Pérez Alberto A Torrents David D Orozco Modesto M

Genome biology 20070101 12

A new method for the prediction of promoter regions based on atomic molecular dynamics simulations of small oligonucleotides has been developed. The method works independently of gene structure conservation and orthology and of the presence of detectable sequence features. Results obtained with our method confirm the existence of a hidden physical code that modulates genome expression. ...[more]

PMID: 18072969

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