Ontology highlight
ABSTRACT:
SUBMITTER: Shehu A
PROVIDER: S-EPMC2248317 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Shehu Amarda A Kavraki Lydia E LE Clementi Cecilia C
Protein science : a publication of the Protein Society 20080301 3
We propose a method to extensively characterize the native state ensemble of cyclic cysteine-rich peptides. The method uses minimal information, namely, amino acid sequence and cyclization, as a topological feature that characterizes the native state. The method does not assume a specific disulfide bond pairing for cysteines and allows the possibility of unpaired cysteines. A detailed view of the conformational space relevant for the native state is obtained through a hierarchic multi-resolution ...[more]