Ontology highlight
ABSTRACT:
SUBMITTER: Dorfman R
PROVIDER: S-EPMC2248329 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Dorfman Ruslan R Sandford Andrew A Taylor Chelsea C Huang Baisong B Frangolias Daisy D Wang Yongqian Y Sang Richard R Pereira Lilian L Sun Lei L Berthiaume Yves Y Tsui Lap-Chee LC Paré Peter D PD Durie Peter P Corey Mary M Zielenski Julian J
The Journal of clinical investigation 20080301 3
Although cystic fibrosis (CF) is a monogenic disease, its clinical manifestations are influenced in a complex manner. Severity of lung disease, the main cause of mortality among CF patients, is likely modulated by several genes. The mannose-binding lectin 2 (MBL2) gene encodes an innate immune response protein and has been implicated as a pulmonary modifier in CF. However, reports have been conflicting, and interactions with other modifiers have not been investigated. We therefore evaluated the ...[more]